A systems biology approach to the digital behaviorome

A review on the feasibility and validity of building the digital behaviorome via sensor data for neuropsychiatric research published in the journal Current Opinion in Systems Biology.

​This review article summarizes how emerging connected technologies (e.g., smartphones and wearables) may provide novel avenues to understand an individual's behavior through the lens of systems biology. First, we surveyed recent research efforts that leveraged the multimodal high temporal resolution data derived from connected devices to build digital phenotypes and/or discover digital biomarkers of the behaviorome. We write this review with a particular emphasis on the detection, diagnosis, and symptom monitoring of neuropsychiatric disorders, as these pathologies may manifest primarily as disruptions to the behaviorome. We then discussed new opportunities and challenges these state-of-art research efforts bring as they intersect with other areas of natural and social sciences. Ultimately, we suggest how incorporating systems biology and connected technologies data can lead to a better understanding of complex neuropsychiatric disorders.